Sergio Colombo is an insurance agent. He had just gone through a divorce so he is a little bit scattered. Wanting to unwind he plans to go to vacation with a magnificent girlfriend but suddenly he is ordered off to Canada in order to sign an important contract. At the airport Colombo accidentally gets on a plane that flies in a direction directly opposite to Canada - to Bankgok.

To Rome with Love nous fait partir à la découverte de la ville éternelle à travers différentes histoires de personnages, de simples résidents ou de visiteurs pour l’été, mêlant romances, aventures et quiproquos.