Un jeune prédicateur charismatique et sa chaude petite amie latina parcourent la Route 66 en arnaquant les petites églises le long du chemin pour découvrir que les faux pouvoirs de guérison qu'il décrit deviennent réels. Les pouvoirs de guérison servent de bénédiction et de malédiction.

Sinaloa hitchhikes into Texas to meet Merle, her half-sister by way of their dead country musician father. As the two get to know each other, Sinaloa's chaotic influence starts to unravel Merle's quiet, comfortable life. While the family music legacy brought Sinaloa to Austin, she won't leave without taking revenge against the people who stole her daddy away years ago.