Ethan Hunt et son équipe s’attaquent désormais à la plus impossible des missions : éliminer le Syndicat, une organisation internationale secrète et sans scrupules. Cette dernière va se révéler aussi puissante que résolue à détruire l’IMF (Impossible Mission Force).

On the hunt for the Russian mobsters that murdered their best friend, football hooligans turned career-criminals, Mike and Eddie are led to Brazil where a major drug deal is set to take place under the cover of the World Cup. Looking to hijack the deal and gain the ultimate redemption, the pair become caught between international drug cartels, local thugs and corrupt police as they are plunged into the murky depths of the Brazilian underworld.