L'agent de la CIA Bryan Mills a beau avoir sauvé sa fille Kim des mains de kidnappeurs Albanais, ses problèmes ne sont pas terminés, puisque le père d'un des kidnappeurs décide de se venger en prenant Bryan et sa femme en otages alors que la famille est en vacances. C'est au tour de Kim de sauver ses parents, en employant les techniques particulières de son père.

A massive explosion rips though a busy street in Istanbul, Turkey. 95 people are dead; 30 Americans and 5 British. The massacre sends shock waves from Turkey to London and Washington, DC. A new terrorist organization is behind the attack. The explosion is just the beginning. Labyrinth' is the code name of the operation conducted by Turkish intelligence to stop a second, more devastating attack that will plunge Turkey, the only democratic Muslim country in the region, into chaos and destroy the fragile balance of the Middle East. After the initial attack, Turkey becomes a battlefront for terrorists and Turkish, British and American intelligence officers. Everyone has his own agenda in the fight that stretches from Istanbul to Eastern Turkey and from Frankfurt to Northern Iraq.